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Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice

Vorvick, MD, Clinical Professor Emeritus, Department of Family Medicine, UW Medicine, School of Medicine, University of Washington, Seattle, WA

This release leads to increased vascular permeability, plasma protein extravasation, white blood cell infiltration, vasodilation, mast cell breakdown, stimulation of meningeal pain receptors, and further release of inflammatory substances (10)

The Phase I study featured adult patients who have obesity or are overweight across three doses

Head-to-head comparison on key outcomes On weight loss, tirzepatide has consistently outperformed semaglutide