the p values were less than 0.05 for comparisons of the results obtained with 50 mg of sildenafil and 10 mg of IN PT-141 to each of 50 mg of sildenafil alone, 100 mg of sildenafil alone, 7 mg of IN PT-141 alone (in normal human volunteers)and 10 mg of IN PT-141 alone (also in normal human voltuneers)
While there is a common claim that malate may offer a synergistic effect with L-citrulline, there is absolutely no evidence that malate offers any benefits on its own or in combination with citrulline [2]
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Anthonymuthu TS, Tyurina YY, Sun WY, Mikulska-Ruminska K, Shrivastava IH, Tyurin VA, et al
doi: 10.1053/j.ajkd.2005.12.036 161
2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines