In fact, BBB changes often appear in the early stages of MS, before the formation of active lesions, which are a significant feature of early-stage MS (252, 253)
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By immunohistochemical analysis, Ki67 and PCNA expressions were significantly higher in the experimental RRM2 -OE-TPC-1 group compared with the control group, while Ki67 and PCNA expressions were significantly lower in the experimental RRM2 -KD-TPC-1 group ( Figure 6H )
Besides, no other behavioral or clinical differences were observed among the three tested groups (Fig
Protege contra radicales libres y dao oxidativo