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Self-directed combination therapy significantly increases the risk of adverse effects and complications
Evidence Snapshot The STEP trials demonstrated significant weight reduction with semaglutide, with gastrointestinal side effects most prominent during dose escalation. Long-term micronutrient outcomes were not primary endpoints
The satiety signal it generates is among the most thoroughly characterized appetite-suppression mechanisms in metabolic research
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Results: The frequency of GG allele carriers of PNPLA3, TT allele carriers of FADS1, and TT allele carriers of FADS2 tended to be higher in the MASLD group, the levels reaching 55%, 23%, and 45%, compared with 30%, 20%, and 30% in the control group, respectively