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In both types of neurons, activation of -adrenoreceptors was necessary for induction of LTP, and activation of 1-adrenoreceptors was necessary for induction of LTD

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It is also known as periorbital hyperpigmentation (POH)

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hospitalization along with rehydration, antibiotics, and octreotide may be indicated in severe cases, and chemotherapy dose reduction is sometimes necessary (Kadowaki 2011