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[DOI] [PMC free article] [PubMed] [Google Scholar] Mikola H., Waris M., Tenovuo J

Three trials have reported results as of mid-2026

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Unlike exogenous GH administration which bypasses the pituitary entirely and suppresses endogenous GH production via negative feedback on the hypothalamic-pituitary axis MK-677 recruits the endogenous pituitary machinery, theoretically preserving somatostatin-mediated feedback regulation

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10.1007/s12013-024-01253-5 175 XinyueZ.DongheH.ChunZ.FengfanY.ZhimeiW.YujiaoG.et al (2024)