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Thus, the increased sensitivity to RSL3 induced by LDHB silencing in A549 cells is not solely dependent on the CoQ-associated defense mechanism, which is consistent with our previously published study showing that LDHB silencing also affects the GSH-associated defense mechanism in KRAS -mutated lung cancer 24

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Despite their abundance, preadipocytes fail to undergo terminal differentiation into mature adipocytes via the activation of the canonical Wnt signaling [40]

In our study, we demonstrated a persistent senescent-inflammatory microenvironment and a p53-serine 15 phosphorylation regulatory mechanism in keloids, which may play crucial roles in the aggression and recurrence of keloids