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Several of the downregulated proteins are centrally implicated in cardiovascular and metabolic pathologies: TNFRSF11B (Osteoprotegerin) has been consistently associated with coronary artery calcification and vascular dysfunction and is known to be upregulated in human vascular smooth muscle cells predisposed to senescence and atherogenesis 6466

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(2019) 30:46276.e6

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These modes of healing have been observed in rodents with transected Achilles tendons

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