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So, what interventions could be recommended for JM to mitigate his cardiovascular risk

From analyzing the pharmacovigilance report and data supported by FDA, it was proclaimed that, on intake of DPP-IV inhibitors, several patients were diagnosed with hypersensitivity and joint pain issues, and in some cases, these drugs have proven to be fatal for patients with a history of pancreatitis (61, 63)

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Can help lower blood pressure and cholesterol levels

This may be quite a new experience for you given that most medications are oral or topical