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Description

However, PROTACs are typically large and highly polar, with molecular weights often exceeding 800 Da---far beyond Lipinski's Rule of Five (Ro5) for orally bioavailable small-molecule drugs

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10.1105/tpc.12.1.97 124 WadaY.TakemuraK.TummalaP.UchidaK.KitagakiK.FurukawaA.et al (2018)

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The short half-life (~15-30 minutes) means each injection provides an acute GH pulse rather than sustained elevation

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