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Limit alcohol consumption, which may dampen the effects of melanocortin receptor activation

This is called oxidative stress

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Keratinocytes interact with immune cells recruited to the site of inflammation and increase the expression of adhesion molecules, which enables immune cells to adhere to the vascular endothelium ( According to the literature, oxidative and nitrosative stress plays a role in the progression of chronic spontaneous urticaria (CSU) ( Table 1 ) (164, 165)

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