Discussion Here, we established a closed loop between supramolecular transformation and genetic response, enabling influxefflux cycles of synthetic nanostructures within living cells, during which intracellular redox and energy homeostasis were restored
Targeting ferroptosis is also regarded as a novel therapeutic strategy for epilepsy associated with mitochondrial dysfunction (Perucca, 2018)
By regulating glutathione S-transferase (GST) and intracellular glutathione (GSH) levels, Nrf2 controls the level of ROS in the cell (Kolls, 2006
Quantitative real-time polymerase chain reaction (qRT-PCR) analysis Cellular RNA was extracted from mouse kidney tissues and HK-2 cells
A deep understanding of this biosynthetic machinery is not merely an academic exercise
This renders the hypothesis of a Ser111/His108 hTrxR1 dyad for deprotonation of Cys497 hTrxR1 unlikely