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LCACs have also been suggested to have dose-dependent inhibitory effects on cardiac K + currents, including the transient outward K + current ( I to ) (Xu and Rozanski, 1998) and ATP-sensitive K + current ( I K,ATP ) (Xu and Rozanski, 1998) and, in the other case, was closely linked to an interaction of I K,ATP lipid gating ( Summary of LCAC Effects on Cardiac Excitation-Contraction Coupling The electrical and mechanical alterations to cardiac muscle induced by LCAC exposure can be attributed to a pleiotropy of modulations in ECC mechanisms

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