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Glial-Derived Neurotrophic Factor (GDNF): The Great Healer If NGF is the architect building new roads, GDNF is the maintenance crew keeping the infrastructure safe, resilient, and fully operational

The largest concern might be that even if the compound continues to show good overall safety data (which it does), adulteration and contamination are genuine black and grey market concerns whilst unregulated

2021 Jul 30;14:3651-3664

Furthermore, this trend toward increased alpha diversity in the obese groups placed on an LD that had consequently experienced weight loss aligns with clinical observations, where low gene richness has been associated with increased adiposity, insulin resistance, and dyslipidemia 70 while increased gene richness has been observed following dietary intervention in obese and overweight individuals 71

DOI: 10.1126/science.119.3097.623 3