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There are at least five significant roadblocks in transforming preclinical results into clinically applicable antibiotics: absence of reliable animal models, high costs as well as low success rates in clinical trials, lack of economic incentives among producers, poorly chosen areas of research, and gaps in implementation of the best antibiotic stewardship practices [276]

In fact, it was the largest study included in the review

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While it is naturally produced in our bodies, our levels decrease as we age, which contributes to changes in skin texture, the appearance of wrinkles, and shifts in skin color