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Narvaez-Vasquez, and C.A

Huo, Samantha et al

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These changes were associated with pronounced morphological changes in the cornea, involving denudation of the corneal stroma, which had already appeared during the period of narcotic sleep, as a result of a large number of deaths of the corneal epithelial cells (Figure 1b, C0)

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Indeed, early presence of hypermethylated TSGs does not necessarily indicate an invasive cancer, as premalignant or cancer precursor lesions can also carry these epigenetic signatures