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The compound binds HGF with sub-nanomolar affinity (Kd 65 pM) and is investigated as a synaptogenic research molecule with notable properties unusual for a peptide: oral bioavailability and blood-brain barrier permeability

It is also involved in regulating neuron and glial homeostasis through regulating ion channels, releasing neurotransmitters, and maintaining synaptic plasticity

By binding with HSA or IgG-Fc, the half-life of protein drugs could be extended

The musculoskeletal side effects include muscle pain, muscle weakness, cramps and swelling in extremities including hands, arms, ankles, feet and/or lower legs

2014;99(4):E729-33