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When ascorbic acid at concentrations above roughly 5% is combined with GHK-Cu in a formulation at pH below approximately 4.5, the reducing environment progressively converts Cu(II) to Cu(I), disrupting the chelation

Pharmacol Rep 63:618628 Pi D, Liu Y, Shi H, Li S, Odle J, Lin X, Zhu H, Chen F, Hou Y, Leng W (2014) Dietary supplementation of aspartate enhances intestinal integrity and energy status in weanling piglets after lipopolysaccharide challenge

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Yanes, D., Nguyen, E., Imadojemu, S