In humans, however, it is common for obese individuals to have the highest levels of circulating leptin, since they have more adipose tissue and develop resistance to the satiety effects of leptin, which is paradoxical since despite that obese subjects have elevated levels of leptin the supply of leptin does not produce a substantial loss of weight, which is attributable to the development of "leptin resistance"
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6a and Supplementary Data 2), and glp-1(-) and mog-3(-) mutants shared ~half of the significantly changed genes
Not all biological, physical, or chemical factors that may promote melanogenesis are known, neither are all the factors that may influence the size, distribution, or intensity of areas of oral pigmentation
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Each rat occupied a minimum space of 2 cubic feet (61 cm 31 cm 31 cm) with softwood shavings as bedding for their comfort