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22 However, the fact that the magnitude and speed of hemoglobin A1c reduction with treatment were identified as risk factors for progression suggests it could be another example of the well-established early worsening phenomenon first observed in type 1 diabetic patients intensively treated with insulin in the Oslo Study, Kroc Collaborative Study and Diabetes Control and Complications Trial

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Biotransformation (drug metabolism) converts the drug in the body to a metabolite that is more readily excreted, usually by adding a chemical group to the molecule to make it more water soluble

This is one of the reasons why research into IGF-1 levels offers such contradictory results

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[13] [14] [17] Other reviews indicate that fructose has no specific adverse effects compared to any other carbohydrate