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These symptoms typically emerge or worsen during treatment initiation and dose escalation, and often improve as the body adjusts to the medication over several weeks

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Both CBS OPT and L2HGDH OPT are about 7KDa larger than the endogenous ones

The cytologic features of congenital melanocytic nevus cells and their patterns of maturation and senescence differ little from those previously described for acquired nevi (68,69)

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