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Nat Rev Mol Cell Biol (2006) 7(7):47383

Over-prescription by healthcare providers for chronic pain that goes beyond recommended guidelines has increased opioid misuse and the health issues and deaths related to it

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It influences the nitric-oxide (NO) system and the dopaminergic and serotonergic systems, which is why anti-inflammatory and gut-brain-axis effects also appear in the literature

It is a multi-organ, temporally resolved biological system that captures pharmacological responses across interconnected physiological networks