Potential impact and next steps By delivering greater weight reduction and metabolic benefits while maintaining a favorable safety profile, the authors say this higher dose could help more people reach their health goals and reduce the burden of obesity-related complications worldwide
It is being studied for healing chronic wounds, burns, and surgical incisions, as well as improving post-surgical recovery and reducing scarring
A 2021 study published in the New England Journal of Medicine (Wilding et al.) found that adults on semaglutide 2.4 mg lost an average of 14.9% of their body weight over 68 weeks, compared to 2.4% in the placebo group
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If you are interested in this medication, here are some practical considerations
GLP-1 RAs may also improve liver function, this effect is thought to involve activation of AMP-activated protein kinase (AMPK), a key metabolic regulator that inhibits fatty acid synthesis and promotes fatty acid -oxidation, leading to decreased lipid accumulation in hepatocytes 22,23,24,25