The company also said it is actively engaging in discussions with the broader congenital HI community, including experts in the field, to develop a path forward based on promising Phase II study results conducted at Childrens Hospital of Philadelphia. Avexitide will join Amylyxs current pipeline, which includes AMX0035 (Relyvrio) for the treatment of Wolfram syndrome, AMX0035 for progressive supranuclear palsy and AMX0114, the companys antisense oligonucleotide targeting calpain-2 for ALS
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and certain undesirable compounds
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Individual responses vary based on the specific medication, dose, and personal gastrointestinal physiology
This is why glycine shows such a pronounced effect in muscle wasting models compared to other amino acids that might only affect one arm of this pathway