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Yoo S-E, Chen L, Na R, Liu Y, Rios C, Van Remmen H et al (2012) Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain

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Similarly, in cells under oxidative stress conditions, activated NRF2 can enhance the expression of MFN1 and MFN2 while degrading DRP2 through the proteasomal pathway, leading to mitochondrial hyperfusion, which temporarily protects cells and alleviates oxidative stress as well as inhibits ferroptosis [109]

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These are important components that help carry oxygen