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[DOI] [PMC free article] [PubMed] [Google Scholar] Becker B., Holtgrefe S., Jung S., Wunrau C., Kandlbinder S., Baier M., Dietz K.J., Backhausen J.E., Scheibe R

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This brief liberation of copper ions triggers a localized inflammatory response, including histamine release that causes the redness and itching many users experience

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Best used by: Those whose dark circles have a brownish pigmentation component that conventional eye brighteners have not adequately addressed, and anyone whose discolouration around the eyes combines both pigmentation and vascular elements and needs a single formula addressing both