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A key therapeutic advantage lies in their dual capacity to sensitize tumors to chemotherapy while protecting healthy tissues from damage
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Polysaccharide fractions Ganoderma atrum polysaccharide (PSG-1) and Ganoderma applanatum polysaccharides (GAP)derived from *Ganoderma lucidum* (tree-leaf reishi)have been demonstrated to ameliorate acrylamide- or cadmium-induced nephrotoxicity, primarily through suppression of the oxidative DNA damage marker 8-hydroxy-2-deoxyguanosine (8-OHdG), restoration of endogenous antioxidant enzyme function, and correction of dysregulated metabolic pathways ( Further investigations have revealed that increased glucose levels can cause advanced glycation end-products (AGEs) to bind to their receptors (RAGE), which in turn activates NOX to produce reactive oxygen species (ROS)
In rats with diabetes induced by STZ, the treatment with HTyr started 7 days before inducing diabetes and continuing for 2 months after (5 mg/Kg/day by gavage) blunted the decrease of retinal ganglion cells, thus exerting a neuroprotective effect [256]
It can indicate bacterial contamination, that the powder hasnt fully dissolved, or a problem with the diluent
