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Disrupted BBB and the blood-cerebrospinal fluid barrier are evident in both sporadic and familial ALS, occurring before the onset of motor neuron degeneration (Fig

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demonstrated that DSIP improved sleep quality in patients experiencing withdrawal-related sleep disturbances, suggesting potential utility in transitioning patients off conventional sleep medications.[3] Other Sleep-Related Peptides While DSIP is the most directly sleep-targeted peptide, several other peptides used in regenerative medicine may indirectly support sleep quality: Growth hormone secretagogues (Ipamorelin, CJC-1295): By stimulating growth hormone release, these peptides may enhance the recovery processes that naturally occur during deep sleep

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