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Corresponding Author E-mail: [email protected] DOI : ABSTRACT: Diabetic wound healing remains a major clinical challenge due to persistent hyperglycaemia-associated metabolic disturbances, oxidative stress, chronic inflammation, impaired angiogenesis, and defective extracellular matrix remodelling

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This more severe kidney injury may reflect early extensive tubular dysfunction in the distal renal tubule or damage at AKI occurrence, further amplifying the discrepancy to milder forms of AKI or those without clinical kidney injury

Given that Tribble et al reported a maximum plasma level of cysteine at approximately 30 minutes to 1 hour after a single oral cysteine administration of approximately 3g, a post hoc analysis comparing plasma cysteine between group 1 (receiving no cysteine) and group 3 (receiving 3g of cysteine) was completed and there was a trend for a greater cysteine concentration at 30 minutes and 1 hour after oral administration (30 minutes: t (14)=1.69, p =0.11