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They stem from dosing mistakes that sabotage results before the first injection even happens

The risk of developing serious complications , while less common, requires vigilant monitoring

Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, in patients with moderate to severe plaque psoriasis: results of a phase III, randomized, controlled trial (Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis [ESTEEM] 1)

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Most patients notice meaningful changes in appetite within the first 2 weeks