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Clinical studies following topical photolyase application have documented reductions in actinic keratoses, improvements in skin texture and tone, and decreased markers of DNA damage in biopsied tissue

So, when you take it doesnt matter, but being consistent does, and choosing a time thats convenient for you will make it easier to stick to the dosage schedule

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Beginner Dose: For beginners, it is advisable to start at the lower end (2040 mcg/day) to assess tolerance and minimize side effects

Interestingly, the decrease in locomotion in SPF mice injected with Ex-4 was more pronounced in the center zone of the OFT but not in the peripheral zone (Supplementary Fig