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the other is that excessive lipid peroxidation leads to the thinning and the increased curvature of the membrane, resulting in membrane instability and micelle formation, eventually causing ferroptotic cell death ( PUFAs in the phospholipids (PLs) of cell membranes, rather than mono-unsaturated FA, cholesterol, and cardiolipin, are highly prone to lipid peroxidation (Yang et al., 2016)

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De Arajo Morais AH, Aquino JS, Da Silva-Maia JK, et al

Mutations in phospholipase DDHD2 cause autosomal recessive hereditary spastic paraplegia (SPG54)

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