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doi: 10.1016/j.bbrc.2018.06.069 64 MadaanANadeau-ValleMRiveraJCObariDHouXSierraEMet al

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Moreover, vitamin D suppresses pro-inflammatory cytokines including TNF- and IL-6, both implicated in obesity-associated insulin resistance (25) These mechanisms are biologically concordant with the established metabolic effects of semaglutide, which include enhancing insulin secretion, reducing glucagon levels, and promoting satiety through central hypothalamic signaling (26)

RCT, randomized controlled trial

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