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Figure 2 5 Immune regulatory mechanisms of PEFs in the TME PEFs (IRE and nsPEF) drive anti-tumor responses by systemically reshaping the myeloid immune landscape: They significantly reduce MDSCs proportions ( + TAM-mediated immunosuppression ( + monocytes into dendritic cells ( 2 NSs captures tumor antigens to form in situ vaccines that promote DC migration ( Figure 3 )

No, neither is FDA-approved for any indication

B12 shots are also highly effective

Clinical decision-making factors include: Treatment goals alignment : Providers must establish whether combination therapy addresses distinct, clinically meaningful objectives that justify added complexity, cost, and potential risk

National Institute on Alcohol Abuse and Alcoholism, 2025)