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Authors contributions Study concept and design (GYW), drafting of the manuscript (EMY, GYW), literature review and writing of the manuscript (EMY), critical revision of the manuscript for important intellectual content (GYW), manuscript proofreading (GYW, EMY)

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Later, Hornig and colleagues also suggested disturbed IL-1 signaling and autoimmunity-type patterns of immune activation while analyzing the cerebrospinal fluid in patients with atypical clinical characteristics (Hornig et al

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Activation of these cells stimulates the secretion of somatostatin, a potent inhibitor that acts locally on neighboring -cells to suppress glucagon release (Zheng et al., 2024)