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When retatrutide binds to GLP-1 receptors, it stimulates insulin release from the pancreas, reduces glucagon secretion, delays gastric emptying, and suppresses appetite through direct signaling to the brain

Soluble fiber supplements like psyllium husk can paradoxically help by firming stools, though these should be introduced gradually after your acute symptoms improve

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In one meta-analysis, Wegovy was found to be more effective for weight loss than phentermine-topiramate

If you have gut inflammation or an imbalance of gut bacteria, it increases your risk of intestinal permeability (what many call leaky gut )