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Furthermore, the GLS2 gene promoter contains a p53 consensus DNA-binding element whose expression was induced in response to oxidative stress [1, 46]

J Nanopart Res 20:11

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Results Increased severity of liver injury and mortality of mice with hepsin deficiency during the early period after acetaminophen exposure To investigate the potential physiological role of endogenous hepsin in the early response to APAP-induced liver injury, we analyzed hepsin expression in wild-type mouse liver lysates following APAP treatment using western blotting (Fig