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To keep GSH in a reduced state, the cytosol and the mitochondrial matrix harbour the NADPHdependent enzyme glutathione reductase (encoded by GLR1 in Saccharomyces cerevisiae )

These superoxide anions are then converted into hydrogen peroxide (H 2 O 2 ) by superoxide dismutase (52)

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Topical Application: Putting Glutathione on Your Face When you apply a glutathione serum or cream to your face, you are delivering the antioxidant directly to the surface of the skin

GHK-Cu is the copper-bound form, used for stability and efficacy

J Transl Med (2013) 11:68