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c Observed percentages of participants who had body weight reductions of 5%, 10%, 15% and 20% from baseline to week 68 (week 104 for STEP 5) during the intrial observation period, based on the number of participants for whom data were available at the week 68 visit (week 104 for STEP 5)

In addition, recent evidence suggests that maintaining serotonin levels plays a role in increasing urethral opening pressure via the 5HT2C pathway, which could explain the success of duloxetine and SNRIs in treating SUI [19]

Losing even 5 to 10 percent of body weight quiets the inflammatory output of fat tissue

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& Roden, M