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First, we employed a series of fluorescent ROS indicators to assess changes in the mediators of oxidative stress (Supplementary Fig

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reconstituted) and the estimated time at elevated temperature

After 4 to 8 weeks on, taking 2 to 4 weeks off and seeing if anything changes gives you some information about whether the compound is producing effects you care about

We have shown that our previously reported potent and selective NSD2 degrader, UNC8732, is metabolized enzymatically and the corresponding aldehyde species effectively recruits FBXO22 to promote ternary complex formation and subsequent degradation of NSD2 (Fig

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