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In some cases, alternative treatments with fewer metabolic effects might be appropriate, or the timing of therapies could be optimised to minimise conflicting effects whilst maintaining therapeutic benefit

Then, the active forms of GLP-1 are extremely susceptible to the catalytic activity of the proteolytic enzyme dipeptidyl peptidase-4 (DPP-4), resulting in the abundant inactivated GLP-1 (936) or GLP-1 (937) amide constituting 6080% of total GLP-1 in circulation