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Additionally, data from a prospective cohort study of 273 patients with premature peripheral arterial occlusive disease showed the same incidence of events in the normohomocysteinemic and vitamin-treated (folic acid plus pyridoxine) hyperhomocysteinemic groups (De Jong et al, 1999b)

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5.1.3.1 Direct suppression of the immune micro-environment by bilirubin Bilirubin acts as an inhibitor at many sites in the immune system, including immune cell proliferation, antibody secretion, and complement activation