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Hydrogen peroxide is known to be a short-lived molecule in cell cultures that is degraded within 30 min

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GSH also detoxifies electrophilic xenobiotics compounds (chemical carcinogens, environmental pollutants, drugs, etc.) and their metabolites to GSH adduct (GS-X) in the direct catalysis of glutathione-S-transferase (GST, primary approach) [32]

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Through endocytic delivery by transfectants, cytoplasmic DNA sensors activate interferon regulatory factor 3 (IRF3) via either the cyclic guanosine monophosphateadenosine monophosphate (cGAMP)STING or receptorinteracting serine/threonineprotein kinase 1/3 (RIPK1/3) signaling cascades, ultimately leading to the production of IFN - [120,121,122]