The most advanced of them, danuglipron, has demonstrated good efficacy in a twice-daily formulation, and we believe a once-daily formulation has the potential to have a competitive profile in the oral GLP-1 space," said Mikael Dolsten, MD., PhD., Chief Scientific Officer & President, Pfizer Research and Development
In one study on the effects of epitalon on rat cells, the peptide induced the active proliferation of the cultured cells. Another study, this time on human fetal tissue, found that epitalon-treated cells demonstrated high telomere lengths, which led the authors to believe that epitalon has some anti-aging capacities
( D F ) TNBC metastatic 4T07 and 4T1 ( D ), D2A1-m1 and D2A1-m2 ( E ), human MDA-MB-468 and MDA-MB-231 ( F ) cells were pre-treated with 10 M FADS2i (SC-26196), FADS1/2i (CP-24879), and SCD1i (CAY10566) for 4 h, exposed for 2 h to 5 M erastin, and subjected to cytofluorimetric analysis to measure lipid peroxidation ( n = 3 biological replicates in either single, duplicate or technical triplicate)
We need more research
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