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within retatrutide's triple-agonist design, this effect is thought to be counterbalanced by concurrent GLP-1 and GIP activity, though this remains under investigation in ongoing trials

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This process increases immunogenicity, which in turn leads to autoimmunity and the development of T1D in genetically predisposed patients (26, 27) ( Figure 1 )

Merz KE, Thurmond DC (2020) Role of skeletal muscle in insulin resistance and glucose uptake

From week 25 onward, the protocol continues at 12mg weekly indefinitely