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Its impact on epidermal stem cells is even more significant

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While GLP-1 agonists (like semaglutide or tirzepatide) take the spotlight for weight loss, emerging research suggests that low-dose GLP-1 blockers may have meaningful anti-inflammatory and immunomodulatory benefits

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Moreover, expression levels of neuronal differentiation 1 ( NEUROD1 ), which is a transcription factor with a critical role in cell fate and maturation (47), follow similar patterns to the aforementioned genes, with the highest expression in the -4 subcluster (Figure 3D)

However, semaglutide is a single GLP-1 agonist, while retatrutide activates three receptor systems simultaneously, making direct comparisons problematic