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For both, the cause is connected to alterations of the functionality of the relative enzymes, such as succinate dehydrogenase (SDH) and fumarate hydratase (FH), respectively, that include loss-of-function mutations, transcript degradation by miRNAs, post-translational modifications, and protein degradation

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doi: 10.1182/blood-2016-10-569186 [DOI] [PubMed] [Google Scholar] 77.Olesen J, Thomsen L, Lassen L, Olesen I

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