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Despite affecting an estimated 190 million women worldwide, the condition continues to evade timely recognition in clinical practice (Zondervan et al., 2020)

That is not always obvious at the time, which is why dose and schedule should be set against a confirmed clinical picture rather than guesswork

ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1

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We can apply a topical anesthetic beforehand to minimize discomfort, although this is rarely necessary

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