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In addition, it has been found that most natural polyphenols play an antioxidant role by activating the Nrf2 and GPX4-related pathways, thereby playing an important role in the treatment of diabetes and its complications (228, 229, 236)

Biomedicines, 10 (5) 1066, 1066

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For instance, in the myocardium of exhaustive-exercised rats, TMZ produced specific cardioprotective outcomes by increasing GSH and GPX activity to clear oxidative stress

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Two studies (Szelestey et al., 2013