This is a significant development because OSA is extraordinarily common, underdiagnosed, and carries real cardiovascular risk through mechanisms including intermittent hypoxia, sympathetic nervous system activation, and systemic inflammation
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An initial incubation of CD16/CD32 Fc Block (BD Biosciences) was followed by staining with the following antibodies, all from BioLegend: CD45-PE/Cy7, CD11b-PE/Cy7, GR-1-BV510, CD41-BV421, CD62p-APC, CD42d-PerCP/Cy5, and F4/80-PE
doi: 10.1111/nph.16636 10 YanHFZouTTuoQZXuSLiHBelaidiAAet al
Phase 2 trial data published in the New England Journal of Medicine in 2023 demonstrated substantial weight reduction up to approximately 24% of body weight over 48 weeks which generated considerable public and media interest